UNA NUOVA TECNICA DI PULIZIA SELETTIVA (selective surgical clearing) DELLE CELLULE CUTANEE INVECCHIATE.
AB53RA è la sigla che designa una delle tecniche propedeutiche della CHIRURGIA COLLAGENOPOIETICA diretta a:
1. Rimuovere le cellule degenerate dermo-epidermiche
2. Attivare lo strato basale (cellule staminali)
3. Stimolare il microcircolo
AB 53 RA
utilizza strumenti microchirurgici, disegnati e realizzati presso il nostro
laboratorio allo scopo di operare su aree di diametro inferiore al
millimetro e asportare strati cellulari in successione.
Il nuovo dispositivo SENOLITICO
1. Permette di MISURARE in MICRON lo strato cellulare da rimuovere, agendo selettivamente sulle cellule cutanee invecchiate.
2. Funziona SENZA ANESTESIA.
3. È INDOLORE.
4. Completa l’INTERA REGIONE FACCIALE in UNA SEDUTA.
Le cellule invecchiate aumentano progressivamente di numero nel corso degli anni. I farmaci senolitici (letteralmente "distruttori della senescenza") sono molecole naturali o di sintesi, che provocano selettivamente la morte delle cellule invecchiate ("apoptosi selettiva").
La chirurgia senolitica utilizza microstrumenti per l’asportazione selettiva delle cellule invecchiate.
Pulizia selettiva delle cellule invecchiate
Pre e Post trattamento dopo una settimana
Dal 1998, anno di sua fondazione, il Centro Ricerche sulla Plasticità Tessutale https://www.biotess.org/ pubblica lavori scientifici e organizza congressi sull’anti-aging e anti-cancerogenesi.
Il Centro Ricerche rappresenta attualmente il polo scientifico di Regenera Clinic Molise.
Senolytic drugs: from discovery to translation
Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach. SC accumulate with ageing and at causal sites of multiple chronic disorders, including diseases accounting for the bulk of morbidity, mortality and health expenditures. The most deleterious SC are resistant to apoptosis and have up-regulation of anti-apoptotic pathways which defend SC against their own inflammatory senescence-associated secretory phenotype (SASP), allowing them to survive, despite killing neighbouring cells. Senolytics transiently disable these SCAPs, causing apoptosis of those SC with a tissue-destructive SASP. Because SC take weeks to reaccumulate, senolytics can be administered intermittently - a 'hit-and-run' approach. In preclinical models, senolytics delay, prevent or alleviate frailty, cancers and cardiovascular, neuropsychiatric, liver, kidney, musculoskeletal, lung, eye, haematological, metabolic and skin disorders as well as complications of organ transplantation, radiation and cancer treatment. As anticipated for agents targeting the fundamental ageing mechanisms that are 'root cause' contributors to multiple disorders, potential uses of senolytics are protean, potentially alleviating over 40 conditions in preclinical studies, opening a new route for treating age-related dysfunction and diseases. Early pilot trials of senolytics suggest they decrease senescent cells, reduce inflammation and alleviate frailty in humans. Clinical trials for diabetes, idiopathic pulmonary fibrosis, Alzheimer's disease, COVID-19, osteoarthritis, osteoporosis, eye diseases and bone marrow transplant and childhood cancer survivors are underway or beginning. Until such studies are done, it is too early for senolytics to be used outside of clinical trials.
Keywords: dasatinib; fisetin; quercetin; senescent cell anti-apoptotic pathways; senolytics; unitary theory of fundamental aging processes.
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