Regenera Clinic Molise - Medicina e Chirurgia Rigenerativa




AB53RA è la sigla che designa una delle tecniche propedeutiche della CHIRURGIA COLLAGENOPOIETICA diretta a:

1. Rimuovere le cellule degenerate dermo-epidermiche

2. Attivare lo strato basale (cellule staminali)      

3. Stimolare il microcircolo  

AB 53 RA utilizza strumenti microchirurgici, disegnati e realizzati presso il nostro laboratorio allo scopo di operare su aree di diametro inferiore al millimetro e asportare strati cellulari in successione.


Il nuovo dispositivo SENOLITICO

1.   Permette di MISURARE in MICRON lo strato cellulare da rimuovere, agendo selettivamente sulle cellule cutanee invecchiate.

2.   Funziona SENZA ANESTESIA.




Le cellule invecchiate aumentano progressivamente di numero nel corso degli anni. I farmaci senolitici (letteralmente "distruttori della senescenza") sono molecole naturali o di sintesi, che provocano selettivamente la morte delle cellule invecchiate ("apoptosi selettiva").

La chirurgia senolitica utilizza microstrumenti per l’asportazione selettiva delle cellule invecchiate.






Pulizia selettiva delle cellule invecchiate




Pre e Post trattamento dopo una settimana


Dal 1998, anno di sua fondazione, il Centro Ricerche sulla Plasticità Tessutale pubblica lavori scientifici e organizza congressi sull’anti-aging e anti-cancerogenesi.

Il Centro Ricerche rappresenta attualmente il polo scientifico di Regenera Clinic Molise.




Senolytic drugs: from discovery to translation

J L Kirkland 1, T Tchkonia 1

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach. SC accumulate with ageing and at causal sites of multiple chronic disorders, including diseases accounting for the bulk of morbidity, mortality and health expenditures. The most deleterious SC are resistant to apoptosis and have up-regulation of anti-apoptotic pathways which defend SC against their own inflammatory senescence-associated secretory phenotype (SASP), allowing them to survive, despite killing neighbouring cells. Senolytics transiently disable these SCAPs, causing apoptosis of those SC with a tissue-destructive SASP. Because SC take weeks to reaccumulate, senolytics can be administered intermittently - a 'hit-and-run' approach. In preclinical models, senolytics delay, prevent or alleviate frailty, cancers and cardiovascular, neuropsychiatric, liver, kidney, musculoskeletal, lung, eye, haematological, metabolic and skin disorders as well as complications of organ transplantation, radiation and cancer treatment. As anticipated for agents targeting the fundamental ageing mechanisms that are 'root cause' contributors to multiple disorders, potential uses of senolytics are protean, potentially alleviating over 40 conditions in preclinical studies, opening a new route for treating age-related dysfunction and diseases. Early pilot trials of senolytics suggest they decrease senescent cells, reduce inflammation and alleviate frailty in humans. Clinical trials for diabetes, idiopathic pulmonary fibrosis, Alzheimer's disease, COVID-19, osteoarthritis, osteoporosis, eye diseases and bone marrow transplant and childhood cancer survivors are underway or beginning. Until such studies are done, it is too early for senolytics to be used outside of clinical trials.

Keywords: dasatinib; fisetin; quercetin; senescent cell anti-apoptotic pathways; senolytics; unitary theory of fundamental aging processes.


Chemical Peeling: A Useful Tool in the Office.

Truchuelo M, Cerdá P, Fernández LF.Actas Dermosifiliogr. 2017 May;108(4):315-322. doi: 10.1016/ Epub 2016 Dec 5.PMID: 27931952 Free article. Review. English, Spanish.

Chemical peeling is a common treatment in cosmetic dermatology. A peel that has been used for many years is trichloroacetic acid. ...We present a practical review of the characteristics, mechanisms of action, indications, and complications of superficial chemical peels …


Skin Resurfacing Chemical Peels.

Samargandy S, Raggio BS.2022 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–.PMID: 31613532 Free Books & Documents.

Chemical peeling, also known as chemexfoliation or chemical exfoliation, is a procedure where a chemical substance applied to the skin causes controlled destruction of the epidermis with or without part of the dermis, leading to skin regeneration and remodeli … 

[Use of organic acids in acne and skin discolorations therapy].

Kapuścińska A, Nowak I.Postepy Hig Med Dosw (Online). 2015 Mar 22;69:374-83. doi: 10.5604/17322693.1145825.PMID: 25811473 Free article. Review. Polish.

It is estimated that P. acnes is responsible for acne in approximately 80% of people aged 11 to 30 [27,40]. Even healed skin lesions can often cause skin discolorations and scar formation [51]. ...Exfoliating treatment using organic acids is called "chemical peel …


Consensus reclassification of inherited epidermolysis bullosa and other disorders with skin fragility.

Has C, Bauer JW, Bodemer C, Bolling MC, Bruckner-Tuderman L, Diem A, Fine JD, Heagerty A, Hovnanian A, Marinkovich MP, Martinez AE, McGrath JA, Moss C, Murrell DF, Palisson F, Schwieger-Briel A, Sprecher E, Tamai K, Uitto J, Woodley DT, Zambruno G, Mellerio JE.Br J Dermatol. 2020 Oct;183(4):614-627. doi: 10.1111/bjd.18921. Epub 2020 Mar 11.PMID: 32017015 Review.

These include peeling skin disorders, erosive disorders, hyperkeratotic disorders, and connective tissue disorders with skin fragility. ...Other disorders with skin fragility, e.g. peeling skin disorders, erosive disorders, hyperkeratotic …


Post-Inflammatory Hyperpigmentation: A Review of Treatment Strategies.

Shenoy A, Madan R.J Drugs Dermatol. 2020 Aug 1;19(8):763-768. doi: 10.36849/JDD.2020.4887.PMID: 32845587 Review.

Post-inflammatory hyperpigmentation (PIH) is a reactive process resulting from increased melanin or abnormal distribution of melanin secondary to inflammatory skin conditions, dermatologic therapies, and external stimuli. Because PIH is a common condition that has a substa …


Effect of chemical peeling on the skin in relation to UV irradiation.

Funasaka Y, Abdel-Daim M, Kawana S, Nishigori C.Exp Dermatol. 2012 Jul;21 Suppl 1:31-5. doi: 10.1111/j.1600-0625.2012.01500.x.PMID: 22626469 Review.

In this article, we reviewed the effect of peeling or peeling agents on the skin in relation to ultraviolet (UV) radiation. ...It is important to understand the effect of peeling agents on photoaged skin and to know how to deal with UV irradiati … 

Is skin microneedling a good alternative method of various skin defects removal.

Zduńska K, Kołodziejczak A, Rotsztejn H.Dermatol Ther. 2018 Nov;31(6):e12714. doi: 10.1111/dth.12714. Epub 2018 Sep 24.PMID: 30246914 Review.

Skin microneedling accelerates the process of skin regeneration through the creation of numerous microinjuries which emerge when skin is deeply punctured with very thin needles. ...Due to the fact that skin microneedling stimulates the synthesis of sig … 

Peeling skin syndrome.

Bansal M, Mahajan S, Sankhwar S, Bansal A.BMJ Case Rep. 2015 Jul 6;2015:bcr2015210902. doi: 10.1136/bcr-2015-210902.PMID: 26150647 Free PMC article.

The role of zinc in the treatment of acne: A review of the literature.

Cervantes J, Eber AE, Perper M, Nascimento VM, Nouri K, Keri JE.Dermatol Ther. 2018 Jan;31(1). doi: 10.1111/dth.12576. Epub 2017 Nov 28.PMID: 29193602 Review.

Nevertheless, these treatments have shown to induce a wide array of adverse effects, including dryness, peeling, erythema, and even fetal defects and embolic events. Zinc is a promising alternative to other acne treatments owing to its low cost, efficacy, and lack of syste …